Search results for "Axon tract"

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Engineered axon tracts within tubular biohybrid scaffolds

2021

[EN] Injuries to the nervous system that involve the disruption of axonal pathways are devastating to the individual and require specific tissue engineering strategies. Here we analyse a cells-biomaterials strategy to overcome the obstacles limiting axon regeneration in vivo, based on the combination of a hyaluronic acid (HA) single-channel tubular conduit filled with poly-L-lactide acid (PLA) fibres in its lumen, with pre-cultured Schwann cells (SCs) as cells supportive of axon extension. The HA conduit and PLA fibres sustain the proliferation of SC, which enhance axon growth acting as a feeder layer and growth factor pumps. The parallel unidirectional ensemble formed by PLA fibres and SC …

Nervous systemmedicine.medical_treatmentBiomedical EngineeringBiocompatible MaterialsAxon tractlaw.inventionCellular and Molecular NeuroscienceDorsal root ganglionTissue engineeringConfocal microscopylawGanglia SpinalmedicineAxonCells CulturedTissue EngineeringChemistryAxon extensionGrowth factorRegeneration (biology)Schwann cell cultureDorsal root ganglion cell cultureHyaluronic acid conduitAxonsNerve RegenerationCell biologymedicine.anatomical_structurenervous systemMAQUINAS Y MOTORES TERMICOSSchwann CellsTERMODINAMICA APLICADA (UPV)Poly-lactic fibres

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